Rejuran is an injectable treatment with polynucleotide (PN) as its primary ingredient, derived from salmon DNA (PDRN). It is also commonly referred to as the "Salmon Injection." Polynucleotides are known for their anti-inflammatory properties and ability to promote microvascular circulation. When injected into areas of concern, they activate cellular regeneration and rejuvenation.
This injection therapy addresses a wide range of concerns -- from age-related issues such as wrinkles and under-eye hollowing to skin troubles including acne, acne scars, and scarring.
Because Rejuran works at the cellular level to rejuvenate the skin from its foundation, its effects do not simply fade over time like hyaluronic acid or Botox injections. With each successive treatment, you will experience a progressive improvement in skin firmness, elasticity, and youthful vitality.

While Rejuran treatment is effective even after a single session, repeated treatments deliver superior results. The recommended protocol is three to four sessions at two- to four-week intervals; however, with conventional Rejuran and Rejuran i formulations, some patients discontinued treatment due to discomfort. Because we want our patients to look forward to their treatment sessions and to experience the full benefits of a complete course, our clinic uses Rejuran HB -- a formulation designed for reduced pain.
Each syringe of Rejuran HB contains 10 mg of polynucleotide, 10 mg of hyaluronic acid, and a local anesthetic, resulting in significantly less discomfort during injection compared to conventional Rejuran. In addition to the standard Rejuran benefits, the inclusion of hyaluronic acid enhances moisturizing effects. It delivers hydration to the skin while promoting deep rejuvenation from within for a dewy, radiant complexion.

Because Rejuran works at the cellular level to rejuvenate the skin from its foundation, each successive treatment delivers a progressive improvement in firmness and elasticity. Repeated treatments yield superior results, with the recommended protocol being three to four sessions at two- to four-week intervals. After completing three to four sessions, Rejuran's effects reach their peak between six months and one year after injection. Effects begin to gradually diminish one to two years after injection. Periodic maintenance injections are recommended to sustain the results.

Fine Lines and Dryness Around the Eyes

Wrinkles that appear around the eyes, forehead, between the eyebrows, and around the mouth with facial expressions are a common concern. In youth, the skin's firmness, elasticity, and thickness allow these lines to quickly disappear. However, as aging and UV damage reduce the skin's resilience and volume, these wrinkles become fixed and remain visible even at rest. This type of wrinkle often does not respond well to Botox injections (which address muscle movement) or hyaluronic acid injections (which add volume). Instead, treatment that rejuvenates the skin itself to restore firmness, elasticity, and thickness is needed. The polynucleotide component in Rejuran(R) activates the skin's natural self-regeneration capacity. By injecting it with ultra-fine needles into and around the wrinkled area, the skin gradually recovers its thickness, moisture retention, and elasticity, reducing the depth and visibility of fine lines and wrinkles.

Those Seeking Firmer, More Resilient Skin

Polynucleotide, the primary component of Rejuran, activates fibroblasts to promote the production of collagen and elastin, addressing concerns such as fine lines, dryness, and loss of skin firmness. It is also expected to stimulate the formation of new capillaries and improve blood circulation in the skin. When injected across the entire face, its anti-inflammatory properties can also help with skin concerns caused by inflammation, including pigmentation, dullness, melasma, facial redness, and inflammatory acne.